Mitochondrial function is differentially affected upon oxidative stress
نویسندگان
چکیده
منابع مشابه
Learning under stress in the adult rat is differentially affected by 'juvenile' or 'adolescent' stress.
Epidemiological studies suggest that childhood trauma is associated with a predisposition to develop both mood and anxiety disorders, while trauma during adolescence is associated mainly with anxiety disorders. We studied in the rat the long-term consequences of 'juvenile' stress, namely stress experienced in a period in which substantial remodelling occurs across species in stress-sensitive br...
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Survival of yeast during starvation has been shown to depend on the nature of the missing nutrient(s). In general, starvation for "natural" nutrients such as sources of carbon, phosphate, nitrogen, or sulfate results in low death rates, whereas starvation for amino acids or other metabolites in auxotrophic mutants results in rapid loss of viability. Here we characterized phenotype, gene express...
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In its canonical role the reverse transcriptase telomerase recovers the telomeric repeats that are lost during DNA replication. Other locations and activities have been recently described for the telomerase protein subunit TERT in mammalian cells. In the present work, using biochemistry, molecular biology, and electron microscopy techniques, we found that in the human parasite Leishmania major,...
متن کاملOxidative Phosphorylation and Mitochondrial Function
tive phosphorylation for ATP homeostasis. The ability to generate ATP depends on O2 and an intact inner mitochondrial membrane. During oxygen deprivation from ischemia (a low blood flow), an inability to generate energy from the electron transport chain results in an increased permeability of this membrane and mitochondrial swelling. Mitochondrial swelling is a key element in the pathogenesis o...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 1999
ISSN: 0891-5849
DOI: 10.1016/s0891-5849(98)00205-6